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The Safe System Approach (SSA) aims to eliminate fatal and serious injury roadway crashes through a holistic view of the road system, moving away from traditional safety analysis based exclusively on historical crash data. One reason for this is the classification of crashes into broad categories (e.g., head-on, sideswipe), which does not capture crash progression or contributing factors. In this context, this paper applies crash sequence analysis to historical crash data and uses the findings to proactively identify safety issues in similar contexts, in alignment with the SSA framework. The method uses sequence-of-events information from crash data to generate clusters of crashes with similar underlying characteristics. Data from fatal and serious injury crashes from urban intersections in the state of Ohio between 2018 and 2022 were used in the analysis. The results show 12 clusters with unique characteristics that consider the sequence of events of each crash. Although derived from crash data, the clusters offer an in-depth understanding of the factors associated with each one and help identify cluster-specific countermeasures related to various SSA elements. State and local jurisdictions can use the presented methodology in transportation safety programs, by focusing on the clusters that represent local challenges or on countermeasures related to the issues of multiple clusters. Finally, the method can also be associated with site-specific analysis, providing a comprehensive toolkit for practitioners.